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Scientific Research Scientific and technological innovation
Scientific and technological innovation Therapeutic area Product lines Win-win cooperation
Scientific and technological innovation

Focus on immune inflammatory diseases, and plan a differentiated layout Aim to create a leading enterprise in the field of external medicine

Technology platforms
Targeting compound discovery and verification platform
Targeting compound discovery and verification platform
The company performs comprehensive assessment based on scientifically verified drug targets in terms of addressing unmet clinical needs, future market value, product competitive edge, druggability, and compound inventive, conducts drug molecular design by virtue of computer-aided drug design and classic drug design method, and preliminarily verifies targeting compounds by means of high throughput screening and virtual screening. The core products offered by the company all are programs with mature therapeutic target in bad need for clinical treatment but difficult to develop.
Leading compound optimization screening platform
Leading compound optimization screening platform
Drugs have an impact in the body based on two premises. First, drugs can interact with therapy-related biomacromolecule binding site (namely pharmacology); second, drugs can pass through barriers and reach target tissues (namely pharmacokinetics). The Company’s leading compound optimization screening platform is mainly developed to optimize target specificity, selectivity, safety and pharmacokinetic properties and more. After rounds of design, synthesis, testing and analysis process, the Company has selected two left and right candidate compounds for exhaustive and rigorous toxicological assessment at last, and obtained preclinical candidate compounds with optimal properties based on the assessment results.
Clinical research technology platform
Clinical research technology platform
The Company has a clinical team that is clinically and professionally experienced. The team works to provide important scientific evidence for pivotal trials by building model simulation technology, guiding clinical plan design of drugs, early exploring clinical dose, selecting Phase II recommended dose and offering support to clinical development strategy of products, to lower the risk of clinical failure to the largest extent. Besides, on the basis of action mechanism and molecular properties of drugs in development, epidemiological characteristics of diseases, clinical diagnosis and treatment and the needs of patients and referring to clinical data of similar targets or indications, differentiated clinical trial schemes pertaining to each main product or indication and multistage-integrated trial designs are formulated. Thereby, clinical test is promoted fast.
Precise drug delivery technology platform
Precise drug delivery technology platform
The development of clinical candidate compound preparation plays a very important role in the process of drug research and development. Preparation development will directly impact drug metabolism, function and safety of drugs in the body, and then directly impact the progress of drug development. The Company’s preparation development team consists of senior scientists with years of experience working at international pharmaceutical companies, who works to develop optimal drug form to realize precise delivery and adequate drug exposure based on their thorough comprehension of compound characteristics, quality requirements and clinical needs, with excellent function guaranteed and untoward effect reduced. This team greatly ensures the quality and advance speed of program, and helps ranking the Company among the top globally or nationwide for the progress of new drug development.
Core technologies
Target analysis and precise screening technology
Computer-aided drug design technology
Leading compound optimization technology
Comprehensive drug screening and evaluation technology
Precision Drug Delivery Systems
Model-informed early drug clinical research technology
Clinical plan design and development
Target analysis and precise screening technology
Identifying drug target is key to the development of a new drug. While project approval of new drug, the Company performs comprehensive analysis from the angle of market demand, and advantages and disadvantages of existing representative target drugs, and select competitive programs of high druggability but difficult to develop for further research based on the scientifically verified drug targets, with an aim to addressing the unmet clinical needs. The Company tracks and adopts the internationally most state-of-the-art biological targets, and competes with the products in development for same targets that are difficult to develop and pertaining to major indications in bad need of therapeutic drugs clinically. Its issuer products have entered the first echelon or are ranking among the top.
Computer-aided drug design technology
Drug molecular design is the basis of research and development of modern innovational small molecular drugs, which refers to building molecular operating process of a new chemical entity with activity predictable through scientific conception and rational strategy. The Company’s new drug research team has experience of research and development at international companies for approximately 20 years.
Leading compound optimization technology
After obtaining leading compound molecules of good biological activity by screening with computer-aided drug design technology, the Company needs to further modify and optimize compound structure with the core pharmacophore reserved based on the physicochemical properties and pharmacokinetic characteristics of leading compound molecules such as solubility, membrane permeability, metabolic stability, body distribution, and target missing. After years of exploration and technology practice accumulation, the Company has improved the physicochemical properties and pharmacokinetic characteristics of leading compound through optimization design of leading compound, prodrug design, soft drug design and crystal optimization study, to meet various clinical needs.
Comprehensive drug screening and evaluation technology
The Company has established a sound DMPK evaluation system for comprehensive evaluation and screening of candidate compounds for in vivo and in vitro activity, mechanism of action, and pharmacokinetic and toxicological characteristics. Pharmacokinetic evaluation platform functions to determine dynamic change of drug concentration in the body via quantitative research of the process of drug in living body (absorption, distribution, metabolism and excretion) together with explaining dynamic rule of drugs in the body using mathematics principles and methods. The Company not only has gathered pharmacokinetic data of plenty of compounds, but also works to predict pharmacokinetic characteristics of compounds by virtue of AI platform (such as big data analysis of molecular fingerprint), so as to help compound screening.
Precision Drug Delivery Systems
Formulation development of candidate compounds plays a very important role in the process of drug research and development, and formulation development directly affects the pharmacokinetics, efficacy and safety of the drug in the human body. The company's formulation development team consists of a group of senior scientists with many years of experience in multinational pharmaceutical companies, and adopts solubilization technology, micro-emulsion drug-carrying technology, and sustained-controlled-release technology by virtue of their in-depth understanding of compound properties, quality requirements and clinical needs. We use solubilization technology, microemulsion drug delivery technology, sustained and controlled release technology and other prescription and process designs to further improve the PK/PD properties of drug molecules, develop optimal formulations, ensure precise drug delivery and achieve adequate drug exposure, thus ensuring excellent drug efficacy and reducing adverse reactions at the same time.
Model-informed early drug clinical research technology
Traditional early stage clinical trials mostly are based on experience and trial-and-error method. The Company applies model-informed drug development (MIDD) that is still in the early stage in China to build model simulation technology to integrate and conduct quantitative research on mass of data and information about disease mechanisms, pharmacology and pharmacodynamics interaction, so as to guide clinical plan design of drugs, exploration of early clinical dose, and selection of Phase II recommended dose, and support clinical development strategy of products.
Clinical plan design and development
The Company has a clinically and professionally experienced clinical team. The team has built an effective clinical design and development platform, enabling the company to perform international multi-center clinical development in China and overseas. On the basis of action mechanism and molecular properties of drugs in development, epidemiological characteristics of diseases, clinical diagnosis and treatment and the needs of patients and referring to clinical data of similar targets or indications, the team has developed differentiated clinical plans for each patient subject. The team has completed patient recruitment with high quality and advanced clinical trials by rationally setting inclusion and exclusion criteria and selecting study endpoint under the help of third-party institute, having realized high clinical development efficiency. The Company has formulated differentiated clinical trial schemes pertaining to each main product or indication and multistage-integrated trial design, and clinical test is promoted fast thereby.
Technological achievements
The Company constantly enhances and improves the construction of the technology platform by virtue of years of technical experience and advanced technologies, and has formed multiple technological achievements. The Company has developed a variety of compounds including PG-011, PG-018 and PG-019 making use of its technology platform, and formed multiple preparation forms (such as hydrogel, ointment, emulsifiable paste, and nasal spray) according to medicinal properties in combination with clinical needs.