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Creating innovative therapeutic solutions from in-depth understanding of disease biology
Disease Type
Atopic dermatitis is also known as atopic dermatitis, atopic eczema, Besnier's somatic itchy rash or genetic allergic eczema.
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Pruritus is a feeling stimulating the desire to scratch. Normally, Pruritus that lasts more than 6 weeks is defined as chronic itching. Chronic pruritus is a very common clinical condition that seriously affects the quality of life of people. Pruritus is associated with skin diseases, but also with a variety of systemic diseases, posing a relatively large challenge for clinical management. The incidence of chronic pruritus among adults has reached more than 10% and up to 60% among the elderly.
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Epidermolysis bullosa (EB) is a rare genetic disorder featuring abnormally fragile epithelial tissue, blisters and erosions of the skin or mucous membranes following minor trauma or friction. As defects in skin integrity can lead to chronic and recurrent wounds, exposing patients to recurrent infections and potentially leading to unwanted fibrosis and deformities as well as skin cancer. The lesions are associated with pruritus and pain. Such complications and symptoms constitute a major burden of disease for patients.
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Membranous nephropathy is a pathomorphologic diagnostic term, which is a common cause of adult nephrotic syndrome characterized by the characteristic pathologic changes of massive immune complex deposition visible on the epithelial side of glomerular capillary collaterals. Clinical manifestations include nephrotic syndrome (massive proteinuria, hypoproteinemia, high edema, hyperlipidemia), or asymptomatic, non-nephrotic range of proteinuria.
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Glaucoma refers to a group of progressive optic neuropathies characterized by degeneration of the retinal ganglion cells and retinal nerve fiber layer, resulting in changes in the optic nerve head. Glaucoma is associated with optic nerve damage induced by intraocular pressure (IOP)-related loss of retinal ganglion cells. Glaucoma is the major cause of irreversible blindness throughout the world.
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